Healthy Volunteer - Alzheimer's Research

Do something amazing - help progress Alzheimer’s Research

We are running a research study aiming to identify Alzheimer’s Disease sooner, before people get any symptoms of memory loss. We are looking for people to join the trial who have no symptoms of memory loss. These appointments are incredibly important. Please inform us if you are unable to attend or if your plans change. By booking an appointment and not showing up, you are taking the slot of someone else.

Participation Requirements:
To take part, participants will need to be/have:
– Aged 55-75
– No diagnosis of MCI, Alzheimer’s or other dementia
– No active cancer within the last 5 years
– No diagnosis of epilepsy
– A list of your current medications (if any)
– A Partner/Study Companion who can provide feedback on your memory.*

*Please note: While you do not need a Study Partner/Study Companion for your first visit, you will need someone who can provide feedback on your memory. This is only necessary if you test positive on the blood test and are suitable for the study. Your Study Partner would need to accompany you to the clinic every six months. If you do not have someone who can fulfill this role, unfortunately, you will not be able to participate.

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Volunteer for Alzheimer's Research

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We are sorry but to take part participants must be between 55-75 years old.

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Research Steps
FAQs
Participation Requirements

What steps are
involved to take part?

We are running this study to help us identify Alzheimer’s Disease sooner in patients – before people get the symptoms of memory loss. There are 3 steps to taking part:

Step 1

You will meet with our doctors to discuss the study and check you are a good fit for it. On this visit, if you are found to be suitable, you will have a blood test that looks for any build-up of proteins in the blood that could indicate possible Alzheimer’s Disease.

Step 2

If found to have elevated levels, we will send you for an MRI scan and a PET scan to determine whether these abnormal proteins are, in fact, due to a build-up of amyloid plaques in the brain.

Step 3

If the PET scan shows this build-up, you can decide if you would like to join the research study. Being a part of the research study would involve taking medication to stop further buildup of this plaque. In other words, this is aims to stop any progression to Alzheimer’s Disease.

FAQs

The blood test in Step 1 is before having an informal chat with a doctor at our clinic. We use them to look for abnormal levels of p-tau217, which have been shown to be an early indicator of Alzheimer’s disease.
The appointment duration varies from site to site. However, it should take up to 45 minutes per person. All that is done on this appointment is:
- Hear from the doctor what the study is about
- A quick telephone-based memory assessment
- Finally, a blood test for ptau-217
If a buildup of p-tau217 is found (usually less than 3% of patients will have this level), it is no guarantee of early Alzheimer’s. We would arrange for two state-of-the-art scans to determine the reason. These scans will involve a 3T MRI looking for abnormalities in the brain (e.g., a silent, benign stroke, which can be normal) and a PET scan, which will quantify the level of amyloid in the brain.
A positive PET scan would allow someone to join the trial, but of course, a patient can withdraw at any stage.
Participation is entirely free as it’s a significant contribution to Alzheimer’s Research.
Yes, travel expenses are reimbursed if you take part in a study. This reimbursement is up to £150.

Participation Requirements

In order to take part, participants will need to be/have:

Aged 55-75
No diagnosis of MCI, Alzheimer's or other dementia
No active cancer within the last 5 years
No diagnosis of epilepsy
A list of your current medications (if any)
A Partner/Study Companion who can provide feedback on your memory.*

*Please Note: While you do not need a Study Partner/Study Companion for your first visit, you will need someone who can provide feedback on your memory. This is only necessary if you test positive on the blood test and are suitable for the study. Your Study Partner would need to accompany you to the clinic every six months. If you do not have someone who can fulfill this role, unfortunately, you will not be able to participate.

Do you meet the requirements and want to help progress Alzheimer’s Research?

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