In the dynamic landscape of medical research and clinical trials, breakthroughs can have far-reaching impacts on healthcare and treatment options. The latest buzz in Alzheimer’s Research revolves around the hope and development of new-generation medications to slow down or halt disease progression, with the latest breakthrough being the results of donanemab.

As a pioneering centre of excellence, Re:Cognition Health was one of the only clinics in the UK to deliver the groundbreaking TRAILBLAZER2 clinical trial, testing the donanemab treatment for Alzheimer’s.

This development marks a significant step forward in the quest for more effective treatments for Alzheimer’s disease, a condition that affects millions worldwide. The trial included 1,736 international participants, 62 from the UK who all participated through Re:Cognition Health’s UK centres in London, Guildford and Birmingham.

The Donanemab Clinical Trial: A Glimpse of Hope

Alzheimer’s disease is a formidable adversary, affecting memory, cognitive function and the overall quality of life for those diagnosed. Amidst the ongoing search for a cure or even an effective treatment to slow its progression, donanemab has emerged as a promising candidate. Donanemab is a monoclonal antibody designed to target and remove amyloid plaques, one of the hallmark features of Alzheimer’s pathology. Amongst all participants on TRAILBLAZER-ALZ 2, amyloid plaque was reduced on average by 84% at 18 months, compared to a 1% decrease for participants on placebo.

Donanemab results:

The results of the TRAILBLAZER-ALZ 2 study show that donanemab:

  • Slowed cognitive decline by 35% compared to the placebo
  • Functional decline, relating to the ability to perform normal daily living such as activities managing finances, engaging in hobbies, conversing about current events and driving- was reduced by 40%, compared to the placebo.
  • Nearly 50% of participants had no clinical progression at 12 months
  • Those at the earliest stage of the disease had the greatest benefit, showing a 60% slowing of decline compared to the placebo.

Re:Cognition Health’s achievement of delivering the donanemab clinical trial brings hope to patients, families and healthcare professionals alike. The trial represents an exciting opportunity to explore new avenues for treating Alzheimer’s, with potential implications that extend beyond the UK borders.

Re:Cognition Health- pioneering change in Alzheimer’s

With a world-leading team of renowned brain and mind experts, Re:Cognition Health is uniquely positioned to contribute to the advancement of Alzheimer’s research. Re:Cognition Health’s comprehensive approach to patient care, cutting-edge facilities and dedication to staying at the forefront of medical innovation have solidified its reputation as a leader in cognitive health. By conducting the donanemab clinical trial, Re:Cognition Health is not only providing patients with an opportunity to change their prognosis, but also playing an integral role in shaping the future of Alzheimer’s treatment strategies.

The Broader Implications

While the primary focus is on the potential impact of the donanemab trial on individual patients, its ripple effects extend far beyond the walls of Re:Cognition Health. The results of the trial, whether they confirm the efficacy of donanemab or provide valuable insights into Alzheimer’s disease mechanisms, could reshape the landscape of neurology and Alzheimer’s treatment globally.

The UK’s participation in the donanemab clinical trial adds to the international effort to tackle Alzheimer’s disease comprehensively. Collaborations between research institutions and healthcare centres across different countries contribute to a broader understanding of the disease and accelerate the development of innovative treatments.

The future:

Re:Cognition Health’s delivery the donanemab clinical trial marks a momentous achievement in the realm of Alzheimer’s research and treatment. This development reflects the dedication to advancing cognitive health, backed by a team of experts committed to making a difference. This milestone of donanemab offers a glimmer of hope for the millions affected by the condition and reaffirms the power of collaborative research in shaping a healthier future for us all.

Re:Cognition Health is currently running TRAILBLAZER-ALZ 6 in its six UK and USA centres, which is testing the Donanemab dosage regimens to reduce the risk of ARIA, where all participants are taking the active medication.

Get involved:

For further information about participating in clinical trials, please visit or call 0800 802 1030



Photo by Anna Shvets


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